Response: CALHM1 Association with Alzheimer's Disease Risk
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چکیده
منابع مشابه
Response: CALHM1 Association with Alzheimer's Disease Risk
ranging from 0.15 to 0.84). Stratification by age of AD onset (using 65 years as cutoff) or APOE ε4-genotype did not appreciably change these results (data not shown; stratified analyses were not possible in the GWAS samples as no onset age or APOE ε4 data were supplied). Effect size estimates indicated insignificant ORs that were opposite in direction to those reported by Dreses-Werringloer et...
متن کاملNo Association between CALHM1 and Alzheimer's Disease Risk
In a recent paper in Cell, Dreses-Wer-ringloer et al. (2008) reported the identification and functional characterization of a new Alzheimer's disease (AD) gene, CALHM1, encoding calcium homeostasis modulator 1. CALHM1 (formerly annotated as FAM26C) represents a compelling candidate gene for late-onset AD as it is located on chromosome 10q24, a consistently replicated AD linkage region (Bertram ...
متن کاملAssociation of CALHM1 Gene Polymorphism with Late Onset Alzheimer's Disease in Iranian Population
Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disease and Late-Onset type (LOAD) is the most common form of dementia affecting people over 65 years old. CALHM1 (P86L) encodes a transmembrane glycoprotein that controls cytosolic Ca(2+) concentrations and Aβ levels and P86L polymorphism in this gene is significantly associated with LOAD in independent case controls in ...
متن کاملassociation of calhm1 gene polymorphism with late onset alzheimer’s disease in iranian population
alzheimer's disease (ad) is a genetically heterogeneous neurodegenerative disease and late-onset type (load) is the most common form of dementia affecting people over 65 years old. calhm1 (p86l) encodes a transmembrane glycoprotein that controls cytosolic ca2+ concentrations and aß levels and p86l polymorphism in this gene is significantly associated with load in independent case controls in a ...
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ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.11.031